Postdoctoral studies in cancer metabolism

We search a postdoctoral fellow for pioneering research on the logic of methionine metabolism in regular and cancerous human cells, utilizing trendy biochemistry and methods biology approaches. You’ll work inside a multidisciplinary staff of experimental and computational scientists, and with nationwide and worldwide collaborators, in the direction of the aim of exact therapeutic interventions in methionine metabolism to fight metabolic illness.

Division

The division of Drugs (Solna) is among the largest at Karolinska Institutet, combining medical and experimental sciences. Our cardiovascular drugs division contains a wealthy number of metabolism-oriented analysis, together with immunometabolism and most cancers metabolism. We’re situated within the model new Bioclinicum analysis constructing on the coronary heart of the Solna campus, in shut proximity to each Karolinska Hospital and the primary analysis amenities of Karolinska Institutet.

Duties

Your mission might be to develop an correct mannequin of methionine metabolism utilizing isotope tracing, flux evaluation strategies and quantitative biochemistry strategies, in collaboration with computational scientists in our staff. Particularly, you’ll examine how methionine metabolism differs between most cancers cells that strictly require methionine and regular cell varieties that don’t. Additionally, you will decide how nutrient ranges may be modulated to induce “methionine disaster” in most cancers cells and thereby stop most cancers development, as a step in the direction of the long-term aim of growing dietary interventions for sufferers. Some technique growth might be concerned to optimize measurements of related metabolites and metabolic fluxes. You might also be concerned in a associated undertaking on methionine metabolism in liver, the place related disturbances in methionine metabolism are recognized to drive steatosis and steatohepatitis.

Entry necessities

We search a extremely motivated, inventive, and impartial scientist with a biotechnology or biochemistry background. The profitable candidate ought to have sturdy expertise in quantitative evaluation work reminiscent of enzyme and metabolite assays. Strong data of mammalian cell biology and mobile metabolism, in addition to expertise with mammalian cell tradition strategies and strategies for assessing cell proliferation, is required. Familiarity with quantitative knowledge evaluation strategies reminiscent of flux stability evaluation, metabolic flux evaluation, metabolic management principle, or different model-based strategies is a bonus. Sturdy aptitude for teamwork and glorious communication expertise in spoken and written English are required.

This appointment might be for 2 years, with a potential transition to employment for a further two years.

Scholarships for postdoctoral qualification may be established for overseas researchers who place their {qualifications} in Sweden. The aim of scholarships for postdoctoral qualification is to advertise internationalization and contribute to analysis qualification after a doctorate or equal.
A scholarship for finishing up postdoctoral analysis may be granted for a most of two years inside a 4 yr interval following the receipt of a doctoral diploma or equal.
To be eligible for a postdoctoral scholarship, the individual will need to have obtained a doctorate or a overseas diploma deemed to be equal to a doctorate. Candidates who haven’t accomplished a doctorate on the finish of the appliance interval might also apply, supplied that each one necessities for a accomplished diploma are met earlier than the (supposed) begin date of the put up doctoral training.

The pinnacle of the division determines whether or not their earlier coaching and scholarly {qualifications} correspond to a Swedish doctorate or greater.

Location

The place is situated inside the Division of Drugs, Solna. The division consists of twelve divisions and every division consists of a number of analysis teams. The place is situated inside the analysis group of Roland Nilsson. Our lab has a broad experience in mobile metabolism, with a deal with most cancers cell metabolism. Our final aim is to take advantage of quantitative data of human metabolism to design simpler therapies of human illness.

Kind of scholarship

The quantity is tax free and it’s set for twelve months at a time, paid out on a six months foundation. In distinctive circumstances, shorter durations could also be acceptable.

Software course of

An software should comprise the next paperwork in English or Swedish:

• A whole curriculum vitae, together with date of the thesis defence, title of the thesis, earlier educational positions, educational title, present place, educational distinctions, and committee work
• A whole checklist of publications
• A abstract of present work (no multiple web page)

The appliance is to be submitted on the Varbi recruitment system.

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