PhD student position in autoimmunity research
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PhD student position in autoimmunity research

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PhD scholar place in autoimmunity analysis

To be a doctoral scholar means to commit oneself to a analysis mission beneath supervision of skilled researchers and following a person research plan. For a doctoral diploma, the equal of 4 years of full-time doctoral schooling is required.

The analysis group

The profitable candidate will work within the staff of Bence Réthi, Aase Hensvold, and Akilan Krishnamurthy in collaboration with Vivianne Malmström and Lars Klareskog on the Division of Rheumatology, Division of Drugs, Solna. Our staff is specialised in learning very early pathological mechanisms that contribute to the event of rheumatoid arthritis (RA). Within the current years, now we have established a novel experimental platform to know how human patient-derived autoantibodies set off pathological modifications in vivo, equivalent to joint ache, bone erosion and irritation. Our findings and experimental fashions have impressed a number of collaborative initiatives with pharmaceutical firms the place we analyse novel early-stage therapies in RA. Along with experimental analysis, we research a big cohort of people prone to growing RA, individuals who carry autoantibodies typical for RA and have musculoskeletal complaints, with the goal of figuring out environmental elements and immune mechanisms that may be linked to RA improvement.

The doctoral scholar mission and the duties of the doctoral scholar

The mission will concentrate on the consequences of various autoantibody clones on RA improvement. These antibodies have been cloned from plasma cells or reminiscence B cells of RA sufferers and acknowledge post-translationally modified proteins (primarily citrullinated or malondialdehyde (MDA)-conjugated proteins). First, we are going to research how T cell mediated mechanisms or inflammatory mediators modulate autoantibody-induced pathways in mice. We can even analyse metabolic modifications induced by anti-MDA antibodies and the impact of those on bone eroding osteoclasts. Along with mouse fashions, the coed will analyse how totally different autoantibody varieties (ranges and fine-specificities) may contribute to the manufacturing of inflammatory mediators and to bone injury in people progressing in direction of RA. The coed will be taught from group members the evaluation of behavioural modifications, bone erosion (X-ray microscopy) and irritation (MRI) in autoantibody-injected mice, along with numerous immunological and molecular methodologies. The coed can even discover ways to work with human samples and take part in epidemiological analyses. The goal is to realize independence in planning and executing experiments and an energetic contribution of the coed in methodological advances, in discussing and publishing outcomes and in growing additional analysis traces. The coed will actively take part in group- and institutional conferences and current his/her outcomes on nationwide and worldwide conferences.

What do we provide?

A inventive and galvanizing setting full of experience and curiosity. Karolinska Institutet is likely one of the world’s main medical universities. Our imaginative and prescient is to pursue the event of data about life and to advertise a greater well being for all. At Karolinska Institutet, we conduct profitable medical analysis and maintain the most important vary of medical schooling in Sweden. As a doctoral scholar you might be supplied a person analysis mission, a well-educated supervisor, an unlimited vary of elective programs and the chance to work in a number one analysis group. Karolinska Institutet collaborates with distinguished universities from all all over the world, which ensures alternatives for worldwide exchanges. You can be employed on a doctoral studentship which implies that you obtain a contractual wage. Workers even have entry to our trendy health club free of charge and obtain reimbursements for medical care.

Eligibility necessities for doctoral schooling

So as to take part within the choice for a doctoral place, you should meet the next normal (A) and particular (B) eligibility necessities at newest by the appliance deadline.

It’s your accountability to certify eligibility by following the directions on the internet web page Entry necessities (eligibility) for doctoral schooling.

A) Common eligibility requirement

You meet the final eligibility requirement for doctoral/third-cycle/PhD schooling for those who:

  1. have been awarded a second-cycle/superior/grasp qualification (i.e. grasp diploma), or
  2. have happy the necessities for programs comprising not less than 240 credit of which not less than 60 credit have been awarded within the superior/second-cycle/grasp stage, or
  3. have acquired considerably equal data in another manner in Sweden or overseas.*

Observe the directions on the internet web page Entry necessities (eligibility) for doctoral schooling.

*When you declare equal data, comply with the directions on the internet web page Assessing equal data for normal eligibility for doctoral schooling.

B) Particular eligibility requirement

You meet the particular eligibility requirement for doctoral/third-cycle/PhD schooling for those who:

– Present proficiency in English equal to the course English B/English 6 at Swedish higher secondary college.

Observe the directions on the internet web page English language necessities for doctoral schooling.

Verification of your paperwork Karolinska Institutet checks the authenticity of your paperwork. Karolinska Institutet reserves the best to revoke admission if supporting paperwork are found to be fraudulent. Submission of false paperwork is a violation of Swedish legislation and is taken into account grounds for authorized motion.

(A) and (B) can solely be licensed by the documentation requirement for doctoral schooling.

Abilities and private qualities

We solely contemplate candidates with real curiosity in immunology and autoimmunity. Good collaboration expertise and a capability of impartial work and drawback fixing are required. Because the initiatives are largely composed of in vivo murine fashions and the analyses of human scientific samples, an affinity to those sorts of research is important. Though the coed can have likelihood to accumulate the experimental expertise wanted for the initiatives, earlier expertise in immunological research and the acquaintance with immunological, molecular and statistical methodologies will probably be positively acknowledged.

Phrases and situations

The doctoral scholar will probably be employed on a doctoral studentship most 4 years full-time.

–[Video about Karolinska Institutet, how we all work towards “a better health for all”] –

Utility course of

Submit your software and supporting paperwork by way of the Varbi recruitment system. Use the button within the high proper nook and comply with the directions. We desire that your software is written in English, however you too can apply in Swedish.

Your software should comprise the next paperwork:

– A private letter and a curriculum vitae
– Diploma initiatives and former publications, if any
– Another documentation exhibiting the fascinating expertise and private qualities described above
– Paperwork certifying your normal eligibility (see A above)
– Paperwork certifying your particular eligibility (see B above)

Choice

A range will probably be made amongst eligible candidates on the idea of the power to profit from doctoral schooling. The {qualifications} of the candidates will probably be evaluated on an general foundation.

Karolinska Institutet makes use of the next bases of evaluation:

– Documented topic data of relevance to the world of analysis
– Analytical ability
– Different documented data or expertise which may be related to doctoral research within the topic.

All candidates will probably be knowledgeable when the recruitment is accomplished.

Location

The employment is on the Division of Drugs, Solna. The Division consists of twelve divisions and every division consists of a number of analysis teams. This place is situated throughout the analysis group of Per-Johan Jakobsson on the Reumatology Division, staff Bence Réthi and Aase Hensvold. The group is situated on the Heart for Molecular Drugs (CMM), cmm.ki.se, on the Karolinska College Hospital space.

Wish to make a distinction? Be a part of us and contribute to higher well being for all

Kind of employment PhD placement
Contract sort Full time
Variety of positions 1
Working hours 100
Metropolis Solna
County Stockholms län
Nation Sweden
Reference quantity STÖD 2-4261/2021
Contact Bence Réthi, +46 704032292
Union consultant Afsar Rahbar OFR, Afsar.Rahbar@ki.seLouisa Cheung, SACO, Louisa.Cheung@ki.se
Revealed 30.Sep.2021
Final software date 21.Oct.2021 11:59 PM CEST

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