PhD Scholarships – ARC Industrial Transformation Training Centre for Cryo-electron Microscopy of Membrane Proteins
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PhD Scholarships – ARC Industrial Transformation Training Centre for Cryo-electron Microscopy of Membrane Proteins

Scholarships

PhD Scholarships – ARC Industrial Transformation Coaching Centre for Cryo-electron Microscopy of Membrane Proteins

Job No.: 625131

Location: Parkville campus

Employment Sort: Full-time

Length: 4-year fixed-term appointment

Remuneration: Tax-free stipend of $33,413 every year

  • Be impressed, day by day
  • Drive your individual studying at one of many world’s prime 80 universities
  • Take your profession in thrilling, rewarding instructions

Everybody wants a platform to launch a satisfying profession. At Monash, we provide the area and help to take your profession in every kind of thrilling new instructions. You’ll have entry to high quality analysis, infrastructure and studying amenities, alternatives to collaborate internationally, in addition to the grants you’ll must publish your work. We’re a college stuffed with energetic and enthusiastic minds, pushed to problem what’s anticipated, develop what we all know, and be taught from different inspiring, empowering thinkers.

Monash College strongly advocates range, equality, equity and openness. We totally help the gender fairness rules of the Athena SWAN Constitution and invite you to hitch us in celebrating ladies in STEMM.

The Alternative

We’re searching for extremely motivated, passionate and aggressive candidates for 4-year totally funded PhD positions within the not too long ago established ARC Centre for Cryo-electron Microscopy of Membrane Proteins. Profitable candidates will be part of the Centre, directed by Professor Patrick Sexton, which is a collaborative enterprise of Monash College (Monash Institute of Pharmaceutical Sciences, Parkville campus), College of Melbourne (Bio21 Institute), College of Wollongong and the Walter and Eliza Corridor Institute.

Concerning the Positions

The profitable candidates might be working in multidisciplinary analysis groups within the new ARC Industrial Transformation Coaching Centre for Cryo-electron Microscopy of Membrane Proteins (CCeMMP), the place we’re working with our companions to boost the utility and utility of cryo-EM to difficult membrane proteins that comprise the most important goal class for therapeutic drug growth.

The Centre gives superior coaching in all elements of membrane protein cryo-EM, together with pattern biochemistry, 3D picture reconstruction, extraction of protein dynamics, and impartial operation of 120kV, 200kV and 300kV devices which can be used for high-resolution construction willpower. Our Doctoral Coaching Program will equip profitable graduates with crucial abilities required for transformative use of cryo-EM for membrane protein drug discovery and growth. The CCeMMP fosters shut partnerships between our university-based researchers and industry-based analysis end-users to offer transformative analysis packages and revolutionary doctoral coaching. Initiatives might embrace mixtures of structural cryo-EM, biochemistry, pharmacology, medicinal chemistry or associated self-discipline.

The CCeMMP is supported by {industry} companions Thermo Fisher Scientific, Servier, AstraZeneca, Pfizer, Dimerix Biosciences, Catalyst Therapeutics, Astex Prescribed drugs, Novo Nordisk, Sanofi-Aventis, Genentech, BioCurate Pty Ltd, FB Rice Pty Ltd, and Clarivate Analytics Ltd.

Monash Node PhD Supervisory Workforce

  • Professor Patrick Sexton
  • Affiliate Professor Denise Wootten
  • Dr Matthew Belousoff

The Monash Nod of the CCeMMP has two main analysis program areas:

  1. Know-how growth
  2. Utility of cryo-EM to discover the construction and performance of GPCRs, and the applying of this data to drug discovery

Venture space 1.1:

Grid design, grid preparation and vitrification applied sciences to boost membrane protein cryo-EM

Venture space 1.2:

Enhancing effectivity and throughput in membrane protein cryo-EM workflows

Venture space 1.3:

Enhancing biochemical approaches to develop the repertoire of GPCR states accessible to cryo-EM

  1. How do distinct detergent and lipid solubilisation environments affect GPCR cryo-EM?
  2. Exploration of approaches to find out Apo GPCR buildings
  3. Exploration of approaches to find out inhibitor-bound, inactive state buildings
  4. Exploration of approaches to find out dimeric (homo-dimer; heterodimer) buildings
  5. Exploration of approaches to find out GPCR buildings with non-canonical transducers, or transducers fro which no present methodologies have been validated for routine use in construction willpower

Venture space 2.1:

Willpower of novel GPCR buildings

  1. Receptors with beforehand decided buildings exploring novel states (splice variants: apo; inhibitor-bound; complexes with totally different transducers; complexes with novel ligands)
  2. Construction willpower for orphan receptors

Venture space 2.2:

Willpower of the connection between ligand efficacy and stability of receptor-transducer complexes for particular person GPCRs and willpower of construction and dynamics of particular person agonist-GPCR complexes of potential therapeutic curiosity

Venture space 2.3:

Decide the connection between ligand efficacy and the flexibility to find out inactive state GPCR buildings for particular person receptors of potential therapeutic curiosity

Additional data on the CCeMMP, the 4-year Doctoral Coaching Program, Analysis Nodes, Program and Venture areas could be discovered at our web site: www.ccemmp.org.

Candidate Necessities

Functions are invited from excellent and enthusiastic graduates with related backgrounds (biophysics, biochemistry, chemistry or equal)

College students might be of a excessive scholarly calibre and can have:

  • A First-Class Honours diploma, Masters diploma or equal
  • Analytical pondering, knowledge evaluation and significant problem-solving abilities
  • Glorious time administration abilities and talent to work independently
  • An in and/or expertise working with {industry} companions
  • Candidates with publications might be extremely regarded
  • Fluency in written and oral English

In accordance with the necessities of the ARC ITTC program, all HDR college students might be required to finish a 12-month {industry} placement throughout their candidature.

Candidates have to be accessible to begin in March 2022

Functions

Expressions of curiosity within the CCeMMP Doctoral Coaching Program are open now.

Candidates should embrace the next when submitting a proper EOI:

  • Resume
  • Cowl Letter
  • Tutorial Transcripts
  • 2 Referees
  • Please establish your program/venture areas of curiosity inside your cowl letter and supply 150 phrases on “Why you have an interest on this program/venture space”

Submissions ought to be made by clicking the “Apply now” button on the Centre web site or by direct e-mail to: ccemmp@monash.edu with the topic line “EOI for the CCeMMP Doctoral Coaching Program”

Further data

Aggressive candidates might be invited to interview with the Centre  HDR committee, who will make suggestions to the Centre Government for Scholarship provides and invites to hitch the CCeMMP Doctoral coaching program.

Functions which can be recognized by the usual Institutional HDR Scholarship means of the person analysis nodes may be thought of. Curiosity within the CCeMMP program have to be clearly recognized.

Enquiries

Casual inquiries are strongly inspired and ought to be directed to the Centre Supervisor, Dr Jackie How, ccemmp@monash.edu

Closing Date 

Sunday 31 October 2021, 11:55 pm AEDT

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