PhD scholarship in Diversity and Evolution of bacterial Biosynthetic Gene Clusters at the Center for Microbial Secondary Metabolites, CeMiSt

PhD scholarship in Diversity and Evolution of bacterial Biosynthetic Gene Clusters at the Center for Microbial Secondary Metabolites, CeMiSt


PhD scholarship in Variety and Evolution of bacterial Biosynthetic Gene Clusters on the Heart for Microbial Secondary Metabolites, CeMiSt

We provide a PhD fellowship at Division of Biotechnology and Biomedicine (DTU Bioengineering) on the Technical College of Denmark. The PhD undertaking is a part of the Heart for Microbial Secondary Metabolites, CeMiSt and will likely be carried out within the Bacterial Interactions and Evolution Group headed by Professor Ákos T. Kovács at DTU Bioengineering and within the Pure Merchandise Genome Mining group headed by Tilmann Weber at DTU Biosustain.

CeMiSt is a Heart of Excellence funded by the Danish Nationwide Analysis Basis. The Heart began in 2018 and can run for six years with an possibility for a four-year extension. The Heart relies on the Technical College of Denmark and hosted by Division of Biotechnology and Biomedicine (DTU Bioengineering). Three DTU departments and 10 senior college take part within the Heart and >15 PhD college students and postdocs are employed. The aim of CeMiSt is to unravel the organic function of microbial secondary metabolites in pure microbiological communities. The Heart is led by Professor Lone Gram.

We’re searching for a candidate to check the variety of bacterial secondary metabolite manufacturing utilizing genome evaluation and metagenome sequencing. You may be concerned in a enjoyable PhD undertaking on bioinformatic evaluation of genome sequences, with sturdy worldwide connections, a productive scientific atmosphere, and an excellent work-life steadiness.

Obligations and {qualifications}
Your PhD undertaking will contribute to our understanding of the variety and evolutionary adjustments of gene clusters associated to microbial secondary metabolite (SM) manufacturing. You’ll carry out bioinformatic evaluation of publicly accessible and in-house sequenced genomes of the Bacillus genus, along with enriched metagenome information. As well as, you’ll decide the genome phylogeny within the Bacillus genus to find out the turnover and evolutionary charges of biosynthetic gene clusters.

Your expertise throughout the areas of computational or evolutionary biology will likely be a bonus, together with:

  • Expertise in working with massive sequencing datasets
  • Data about genome and/or metagenome sequence evaluation and meeting methods
  • Expertise in R or ideally Python
  • Data about evolutionary fee evaluation and evolutionary concept

Earlier information about microbial secondary metabolite biosynthesis and expertise with DNA extraction is advantageous or the willingness to study is required. You might collaborate with pure product chemistry scientists to elucidate constructions of key compounds related to the biosynthetic gene clusters.

Anticipated beginning date: December 2021 or shortly thereafter.

It’s essential to have a two-year grasp’s diploma (120 ECTS factors) molecular biology, biology, engineering or an identical diploma with an educational stage equal to a two-year grasp’s diploma.

Approval and Enrolment
The scholarship for the PhD diploma is topic to tutorial approval, and the candidate will likely be enrolled in one of many basic diploma programmes at DTU. For details about our enrolment necessities and the overall planning of the PhD examine programme, please see the DTU PhD Information.

The evaluation of the candidates will likely be made by by Professor Ákos T. Kovács and Professor Tilmann Weber.

We provide
DTU is a number one technical college globally acknowledged for the excellence of its analysis, training, innovation and scientific recommendation. We provide a rewarding and difficult job in a global atmosphere. We attempt for educational excellence in an atmosphere characterised by collegial respect and an educational freedom tempered by duty.

Wage and appointment phrases
The appointment will likely be primarily based on the collective settlement with the Danish Confederation of Skilled Associations. The allowance will likely be agreed upon with the related union. The interval of employment is 3 years.

You possibly can learn extra about profession paths at DTU right here.

Additional data
Additional data could also be obtained from Professor Ákos T. Kovács, tel.: +45 4525 2527,  

Please don’t ship functions to this e-mail tackle; observe the digital utility and submission process as defined under.

You possibly can learn extra about DTU Bioengineering on and a DTU podcast introduces the Heart that can also be described at

If you’re making use of from overseas, chances are you’ll discover helpful data on working in Denmark and at DTU at DTU – Transferring to Denmark.

Please submit your on-line utility no later than 24 September 2021 (Danish time).

Functions have to be submitted as one PDF file containing all supplies to be given consideration. To use, please open the hyperlink “Apply on-line”, fill within the on-line utility kind, and fix all of your supplies in English in a single PDF file. The file should embrace:

  • A letter motivating the applying (cowl letter) – Please present contact particulars for 2 referees in your motivation letter.
  • Curriculum vitae
  • Grade transcripts and BSc/MSc diploma
  • Excel sheet with translation of grades to the Danish grading system (see tips and Excel spreadsheet right here)

You might apply previous to ob­tai­ning your grasp’s diploma however can’t start earlier than having obtained it.

All candidates no matter age, gender, race, incapacity, faith or ethnic background are inspired to use.

The Heart for Microbial Secondary Metabolites goals to determine what impact microbial secondary metabolites have on different microorganisms of their pure atmosphere. We now have historically perceived them as ‘competitors substances’, however in pure environments they’re hardly ever produced in portions of antibiotic impact. The Heart’s speculation is that secondary metabolites represent a community of sign molecules that instantly have an effect on gene expression, behaviour, and metabolism of the microorganisms and thus play a decisive function within the composition and performance of microbiological communities. We are going to discover this in an interdisciplinary collaboration with the usage of sequence-based, analytical-chemical, molecular, bioinformatic, and traditional microbiological strategies.

The Division of Biotechnology and Biomedicine (DTU Bioengineering) addresses challenges of societal and scientific significance inside biotechnology, biomedicine, meals expertise and human well being. The division relies on each fundamental and utilized analysis and employs instruments from biochemistry, biophysics, chemistry, mobile biology, immunology, microbial ecology and physiology, bioinformatics and bio-engineering. Analysis is carried out inside three fundamental areas: Microbial ecology and physiology, Industrial biotechnology and cell factories, and Biomedicine and well being. The division has intensive collaboration with nationwide and worldwide analysis items and industries. DTU Bioengineering has approx. 300 staff, of which 2/3 is scientific employees. The division is positioned at DTU Lyngby Campus.

Know-how for individuals
DTU develops expertise for individuals. With our worldwide elite analysis and examine programmes, we’re serving to to create a greater world and to resolve the worldwide challenges formulated within the UN’s 17 Sustainable Growth Objectives. Hans Christian Ørsted based DTU in 1829 with a transparent imaginative and prescient to develop and create worth utilizing science and engineering to learn society. That imaginative and prescient lives on in the present day. DTU has 12,900 college students and 6,000 staff. We work in a global ambiance and have an inclusive, evolving, and casual working atmosphere. DTU has campuses in all elements of Denmark and in Greenland, and we collaborate with the perfect universities all over the world.

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Apply no later than 24 September 2021
Apply for the job at DTU Bioengineering by finishing the next kind.

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