PhD Place – Proteome dynamics below mechanical stress
Be part of us for an thrilling PhD venture inside the DFG-funded analysis unit FOR2743 “Mechanical Stress Safety”! Mechanical stress impacts virtually each cell within the human physique, however the molecular mechanisms permitting cells to reply and adapt to those forces are nonetheless incompletely understood. In earlier work, our group on the Central Institute for Engineering, Electronics and Analytics (ZEA-3) along with the Institute of Organic Data Processing (IBI-2), have established in vitro assays for proteome evaluation after managed utility of mechanical stress. This allowed us to recognized autophagy as a significant factor in mobile adaptation. We now try to acquire a systems-level understanding of protein degradation and autophagy below mechanical stress, each in vitro in cell-based techniques in addition to in vivo in tissues of chosen fashions comparable to mice with genetically impaired capability for mechanoadaptation. Additional data on the analysis unit is obtainable at https://www.for2743.uni-bonn.de/information
We need to recruit a
- Proteome evaluation of cells, tissues, and enriched subcellular fractionations, together with pattern preparation, knowledge acquisition and bioinformatics evaluation
- Adapt and develop new protocols for the characterization of autophagy targets
- Carry out cell organic experiments, together with cell tradition and utility of mechanical stress
- Contribute to mass spectrometry instrument operation and upkeep
- Current outcomes at nationwide and worldwide conferences and publish in peer reviewed journals
- Contribute to supervision of internship and BSc/MSc thesis college students
- Grasp´s diploma in analytical chemistry, biochemistry, cell biology or a associated area with a superb remaining grade (equal to grade 2.0 or higher within the German grade system)
- Expertise in cell biology and biochemistry
- Curiosity and motivation paired with an inherent ability for dependable self-organized work
- Sturdy communication expertise in English (fluent)
- Earlier expertise in proteomics, mass spectrometry, and large-scale knowledge evaluation is strongly most well-liked
We work on the very newest points that influence our society and are providing you the possibility to actively assist in shaping the change! We provide ultimate situations so that you can full your doctoral diploma:
- A extremely motivated working group in addition to a world and interdisciplinary working setting at one in every of Europe’s largest analysis institutions
- Participation within the interactive multidisciplinary analysis unit FOR 2743, with optimum situations for collaboration and coaching
- Additional improvement of your private strengths, e.g. by an intensive vary of coaching programs; a structured program of continuous training and networking alternatives particularly for doctoral researchers by way of JuDocS, the Jülich Middle for Doctoral Researchers and Supervisors: https://www.fz-juelich.de/judocs
- Wonderful experimental services at ZEA-3 (Analytics) and IBI-2 (Biomechanics)
- Supportive supervision and a extremely collaborative and interdisciplinary group
- A big analysis campus with inexperienced areas, providing the absolute best means for networking with colleagues and pursuing sports activities alongside work
- Focused providers for worldwide staff, e.g. by our Worldwide Advisory Service
The place is initially for a hard and fast time period of three years and accessible from Sept 1st, 2021. Pay consistent with 65% of pay group 13 of the Collective Settlement for the Public Service (TVöD-Bund) and moreover 60 % of a month-to-month wage as particular fee („Christmas bonus“). Additional data on doctoral levels at Forschungszentrum Jülich together with our different places is obtainable at: www.fz-juelich.de/gp/Careers_Docs
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